Collection of Czechoslovak Chemical Communications p. 1967 - 1981 (1992)
Update date:2022-08-04
Topics:
Butora, Gabriel
Blaha, Ludvik
Rajsner, Miroslav
Helfert, Ivan
Some new analogues of verapamil (Ia) and mepamil (Ib), calcium antagonists of arylkylamine type, were synthesized and screened for cardiovascular activities.The basic structure was modified a) on the phenyl ring, attached to the quaternary carbon, b) on the alkyl group, attached to the quaternary carbon and c) on the alkylamino group, attached in position 3 to the n-propyl fragment.Except of 2-(2-chlorophenyl)-2-isopropyl-5-(N-methylhomoveratrylamino)valeronitrile (VIa), all the synthesized compounds exhibited lower hypotensive activity, than the mother compound, verapamil.
View MoreShanDong XinDa Chemical CO.,LTD
Contact:086-0311-87580543
Address:No.168, High Technology Development Zone Jinan Shandong China
hangzhou verychem science and technology co.ltd
website:http://www.verypharm.com
Contact:+86-571-88162785; 88162786
Address:F1502, 753 Shenhua road, Hangzhou, China
Guangzhou PI & PI Biotech Inc. Ltd.
Contact:+86-20-81716320
Address:Suite 501,198 Kaiyuan Ave.,Science City, Guangzhou,China
Tianjin Jiuri New Materials Co., Ltd.
Contact:+86-22-58889220
Address:C-5/6, Vison Hill, No.1 Gonghua Road, Huayuan Hi-tech Park, Tianjin, China.
website:http://www.sigmaaldrich.com
Contact:800 558-9160
Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland
Doi:10.1021/jo00055a008
(1993)Doi:10.1021/jo050570n
(2005)Doi:10.1016/S0022-1139(00)83887-7
(1991)Doi:10.1016/j.tetlet.2016.09.003
(2016)Doi:10.1080/17415993.2015.1007142
(2015)Doi:10.1246/cl.1992.2393
(1992)