Carbohydrate Research p. 23 - 36 (1992)
Update date:2022-07-30
Topics:
Briggs, Josie C.
Haines, Alan H.
Taylor, Richard J. K.
Dawson, Alan P.
Gibson, I.
et al.
A series of analogues of diacylglycerol has been prepared and tested as inhibitors of protein kinase C (PKC).The diketone analogues, 10-hydroxymethyl-8,13-eicosanedione (24), 10-acetoxymethyl-8,13-eicosanedione (25), and 10-methoxymethyl-8,13-eicosanedione (26) each inhibited PKC activated by 2-O-acetyl-1-O-oleoylglycerol.Compound 24 was the most effective inhibitor of the growth of MR4 and HT29 cells in culture, and 26 was more effective than 24 against HL60 cells.
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