Tetrahedron p. 2805 - 2828 (1993)
Update date:2022-08-02
Topics:
Chen, Shu-Hui
Huang, Stella
Wei, Jianmei
Farina, Vittorio
Several Lewis acids were shown to cleanyl open the oxetane ring of taxol and baccatin derivatives.The reaction is shown to proceed via anchimeric assistance by the C-4 acetate group.Several minor products, including a novel derivative possessing a bridged C-ring, were also isolated.A mechanistric rationale is provides for all compounds formed.When taxol derivatives were treated with Lewis acids in methanol, ester cleavage reactions were observed.We provide conditions that are selective for C-10 acetate cleavage and for C-13 side-chain methanolysis.
View Morezhengzhou Triz Pharma-Tech Co., Ltd
website:http://www.Trizpharma-tech.com
Contact:+86-0371-86597269,53392065
Address:High-tech Industrial Development Zone, Zhengzhou City, NO.7 Holly Street
Shaanxi King Stone Enterprise Company Limited
Contact:86-29-88353805,13609285751
Address:.209 Keji Road Hi-Tech industrial Develpment Zone .Xian China
Guangzhou Chemical Reagent Factory
Contact:+86-20-8435 9820 or 8435 7345
Address:Southern Guangzhou, Guangdong, China
Shanghai Forever Synthesis Co.,Ltd.
Contact:021-61124658
Address:Zhoukang Road,Pudong New District,Shanghai,China
Shandong Topscience Biotech Co., Ltd.
Contact:0633-2619278
Address:No. 98 Lanshan West Road, Lanshan District, Rizhao, Shandong Province, P.R. of China
Doi:10.1016/S0040-4039(00)77630-1
(1993)Doi:10.1002/jhet.5570290509
(1992)Doi:10.1016/S0960-894X(01)00330-4
(2001)Doi:10.1016/S0957-4166(00)86295-3
(1994)Doi:10.1021/jo00068a056
(1993)Doi:10.1021/jo00070a049
(1993)