Collection of Czechoslovak Chemical Communications p. 245 - 251 (1998)
Update date:2022-08-04
Topics:
Olaszova, Eva
Paulikova, Ingrid
Helia, Otto
Svajdlenka, Emil
Devinsky, Ferdinand
Lacko, Ivan
Microsomal esterases were used in (he study of the m vitro enzymic hydrolysis of the ester bond in alkyl(2-benzoyloxyethyl)dimethylammonium bromides. These compounds are potential "soft" disinfectants, easily biodegradable to nontoxic biologically inactive hydrolytic products, namely substituted choline and benzoic acid. Formation of the latter product was used to monitor the kinetics of the reaction. It has been found that the rate of enzymic hydrolysis is substantially influenced by different length of the alkyl chain on the ammonium nitrogen. At the same time, interspecies (rat-mouse) and interorgan (liver-kidney) variability has been observed.
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