Bioorganic and Medicinal Chemistry Letters p. 315 - 320 (1997)
Update date:2022-08-05
Topics:
Sample, J. Edward
Rowley, David C.
Brunck, Terence K.
Ripka, William C.
Molecular modeling and topographic considerations of the thrombin-specific sequences Boc-Asp-Pro-Arg-TS or Ac-d-Phe-Pro-Arg-TS (TS = transition state analog electrophilic center) and related scaffolds led to the design of novel P2-P4-azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives (3a-j). The synthesis and biological activity of these potential serine protease inhibitors are presented.
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