Organic Letters
Letter
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ASSOCIATED CONTENT
* Supporting Information
Detailed experimental procedures and complete character-
izations of the 1,2-addition products (NMR spectra, HPLC
chromatograms of racemic and enantioenriched compounds,
IR, HRMS and melting points). This material is available free of
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S
(12) (a) Shintani, R.; Takeda, M.; Soh, Y.-T.; Ito, T.; Hayashi, T. Org.
Lett. 2011, 13, 2977. (b) Luo, Y.; Carnell, A. J.; Lam, H. W. Angew.
Chem., Int. Ed. 2012, 51, 6762.
AUTHOR INFORMATION
Corresponding Author
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(13) (a) Wu, H.-L.; Chen, C.-C.; Liu, C.-C. Wei, W.-T. Fang, J.-H.
U.S. Pat. Appl. 2013/0096348 A1. (b) Chung, Y.-C.; Janmanchi, D.;
Wu, H.-L. Org. Lett. 2012, 14, 2766. (c) Liu, C.-C.; Janmanchi, D.;
Chen, C.-C.; Wu, H.-L. Eur. J. Org. Chem. 2012, 2503. (d) Wei, W.-T.;
Yeh, J.-Y.; Kuo, T.-S.; Wu, H.-L. Chem.Eur. J. 2011, 17, 11405.
(e) Huang, K.-C.; Gopula, B.; Kuo, T.-S.; Chiang, C.-W.; Wu, P.-Y.;
Henschke, J. P.; Wu, H.-L. Org. Lett. 2013, 15, 5730.
(14) Chen, C.-C.; Pan, J.-H.; Gopula, B.; Wu, P.-Y.; Henschke, J.-P.;
Wu, H.-L. Under peer review.
(15) (a) See: International Conference on Harmonisation (ICH),
guideline Q3C (R5): Impurities: Guideline for Residual Solvents; 2011.
(b) Laird, T. Org. Process Res. Dev. 2012, 16, 1.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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Dedicated to Professor Biing Jiun Uang (National Tsing Hua
University, Hsinchu, Taiwan, ROC) on the occasion of his 60th
birthday. Financial support provided by the National Science
Council of Republic of China (NSC-100-2113-M-003-009-
MY2) and the National Taiwan Normal University is gratefully
acknowledged.
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(b) Reddy, L. R.; Das, S. G.; Liu, Y.; Prashad, M. J. Org. Chem. 2010,
75, 2236. (c) Leemans, E.; Mangelinckx, S.; Kimpe, N. D. Chem.
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