Journal of Organic Chemistry p. 6596 - 6608 (1993)
Update date:2022-08-03
Topics:
Kalivretenos, Aristotle G.
Nakanishi, Koji
Philanthotoxin (PhTX-433), a potent noncompetitive inhibitor of the L-glutamate receptors and the nicotinic acetylcholine receptors of vertebrates and invertebrates, has a butyryl-tyrosyl-thermospermine structure.Several synthetic analogs of PhTX with hydrophobic alkyl branches in the polyamine chain exhibit 6- to 10-fold enhanced activities to various receptors.Because the branched analogs exhibit such unique activities and because of their importance in tertiary structural studies of ligand/receptor binding, methods for preparing branched PhTX analogs, including photolabile analogs, are presented.
View MoreContact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Zhengzhou Minzhong Pharmaceutical Co.,ltd
Contact:0086-371-65797115
Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
Jiangsu Hualun Chemical Industry Co., Ltd
website:http://www.hualunchem.com
Contact:+86-0514-86464168 86507985
Address:39# Middle Renmin Road, Dinghuo Town
TIANJIN FESTO CHEMICAL CO.,LTD
Contact:86-22-25814570
Address:No.12th,5th Ave.,TEDA,Tianjin,China
Nanjing Fubang Chemical Co.,Ltd
Contact:+86-25-83179199
Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China
Doi:10.1002/hlca.19930760521
(1993)Doi:10.1021/jm960586t
(1997)Doi:10.1021/ja411204d
(2014)Doi:10.1080/00958972.2013.867031
(2013)Doi:10.1021/jm00030a004
(1994)Doi:10.1039/c39930001442
(1993)