N-TOSYL-1,4,5,6-TETRAHYDROPYRIMIDINES
3149
(i) Dowling, J. E.; Chuaqui, C.; Pontz, T. W.; Lyne, P. D.; Larsen, N. A.; Block, M. H.;
Chen, H.; Su, N.; Wu, A.; Russell, D.; Pollard, H.; Lee, J. W.; Peng, B.; Thakur, K.; Ye,
Q.; Zhang, T.; Brassil, P.; Racicot, V.; Bao, L.; Denz, C. R.; Cooke, E. Potent and selec-
tive inhibitors of CK2 kinase identified through structure-guided hybridization. ACS
Med. Chem. Lett. 2012, 3, 278–283; (j) Moreno, E.; Plano, D.; Lamberto, I.; Font, M.;
Encıo, I.; Palop, J. A.; Sanmartın, C. Sulfur and selenium derivatives of quinazoline
and pyrido[2,3-d]pyrimidine: Synthesis and study of their potential cytotoxic activity
in vitro. Eur. J. Med. Chem. 2012, 47, 283–298.
2. (a) Ghanim, M.; Lebedev, G.; Kontsedalov, S.; Ishaaya, I. Flufenerim, a novel insecticide
acting on diverse insect pests: Biological mode of action and biochemical aspects. J. Agric.
Food Chem. 2011, 59, 2839–2844; (b) Navarro, S.; Perez, G.; Navarro, G.; Mena, L.; Vela,
N. Influence of fungicide residues on the primary fermentation of young lager beer. J.
Agric. Food Chem. 2007, 55, 1295–1300; (c) Sarmah, A. K.; Sabadie, J. Hydrolysis of sul-
fonylurea herbicides in soils and aqueous solutions: A review. J. Agric. Food Chem. 2002,
50, 6253–6265; (d) Dec, J.; Haider, K.; Rangaswamy, V.; Schaeffer, A.; Fernandes, E.;
Bollag, J.-M. Formation of soil-bound residues of cyprodinil and their plant uptake. J.
Agric. Food Chem. 1997, 45, 514–520; (e) Nezu, Y.; Miyazaki, M.; Sugiyama, K.;
Kajiwara, I. Dimethoxypyrimidines as novel herbicides, part 1: Synthesis and herbicidal
activity of dimethoxyphenoxyphenoxypyrimidines and analogues. Pestic. Sci. 1996, 47,
103–113
3. (a) Xu, C.; Dong, X.-M.; Wang, Z.-Q.; Hao, X.-Q.; Li, Z.; Duan, L.-M.; Ji, B.-M.; Song,
M.-P. Triphenylphosphine-cyclometallated iridium(III) pyrimidine complexes: Synthesis,
crystal structures, and application in a-alkylation of ketones with alcohols. J. Organomet.
Chem. 2012, 700, 214–218; (b) Lippert, B.; Miguel, P. J. S. Metallatriangles and metallas-
quares: The diversity behind structurally characterized examples and the crucial role of
ligand symmetry. Chem. Soc. Rev. 2011, 40, 4475–4487; (c) Parizel, N.; Ramırez, J.; Burg,
C.; Choua, S.; Bernard, M.; Gambarelli, S.; Maurel, V.; Brelot, L.; Lehn, J.-M.; Turek, P.;
Stadler, A.-M. Modulation of self-assembly and magnetism of Cu(II) grids in solution.
Chem. Commum. 2011, 47, 10951–10953; (d) Hildebrandt, B.; Reiß, G.; Ganter, C. The
first structurally characterized N-heterocyclic carbene complex with a ligand derived from
pyrimidine. J. Organomet. Chem. 2010, 695, 474–477.
4. (a) Xue, W.; Li, L.; Li, Q.; Wu, A. Novel furo[2,3-d] pyrimidine derivative as fluorescent
chemosensor for HSO4ꢁ. Talanta. 2012, 88, 734–738; (b) Lin, L.-Y.; Tsai, C.-H.; Wong,
K.-T.; Huang, T.-W.; Wu, C.-C.; Chou, S.-H.; Lin, F.; Chen, S.-H.; Tsai, A.-I. Efficient
organic DSSC sensitizers bearing an electron-deficient pyrimidine as an effective
Q
-spacer. J. Mater. Chem. 2011, 21, 5950–5958; (c) Arrachart, G.; Carcel, C.; Moreau,
J. J. E.; Hartmeyer, G.; Alonso, B.; Massiot, D.; Creff, G.; Bantignies, J.-L.; Dieudonne,
P.; Man, M. W. C.; Althoff, G.; Babonneau, F.; Bonhomme, C. Organosilicas based on
purine–pyrimidine base pair assemblies: A solid state NMR point of view. J. Mater.
Chem. 2008, 18, 392–399; (d) Liu, B.; Zhang, H.-L.; Liu, J.; Zhao, Y.-D.; Luo, Q.-M.;
Huang, Z.-L. Novel pyrimidine-based amphiphilic molecules: Synthesis, spectroscopic
properties and applications in two-photon fluorescence microscopic imaging. J. Mater.
Chem. 2007, 17, 2921–2929; (e) Wang, C.; Jung, G.-Y.; Batsanov, A. S.; Bryce, M. R.;
Petty, M. C. New electron-transporting materials for light-emitting diodes: 1,3,4-Oxadia-
zole–pyridine and 1,3,4-oxadiazole–pyrimidine hybrids. J. Mater. Chem. 2002, 12, 173–
180; (f) Wang, J.-H.; Shen, Y.-Q.; Si, J.-H. Synthesis and solid-state polymerization of
5-(p-methylthio-o-methyl-pyrimidinyl)-2,4-pentadiyn-1-ol and the third-order optical
nonlinearity of its derivatives. J. Mater. Sci. 2000, 35, 5981–5987.
5. [3 þ 3] Two-component cyclization: (a) Burgula, L. N.; Radhakrishnan, K.; Kundu, L. M.
Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method.
Tetrahedron Lett. 2012, 53, 2639–2642; (b) Mokhtar, M.; Saleh, T. S.; Basahel, S. N.