Organic Letters
Letter
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Figure 2. Fluorescence emission spectra of a modified DHFR (Trp-1
at position 17) (red) and wild-type DHFR (blue). λex = 260 nm.
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ASSOCIATED CONTENT
* Supporting Information
■
C.; Schultz, P. G. Nucleic Acids Res. 1989, 17, 9649.
S
Experimental procedures, characterization data, and spectra are
included. This material is available free of charge via the
AUTHOR INFORMATION
Corresponding Author
■
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
We thank Drs. Stephen Benkovic and C. Tony Liu,
Pennsylvania State University, for helpful discussions regarding
the photophysical properties of the Trp derivatives, and for a
critical reading of the manuscript. This work was supported by
NIH research Grant GM 092946.
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