Synthesis of Benzo-Fused Benzodiazepines Employed as Probes of the Agonist Pharmacophore of Benzodiazepine Receptors

DOI: 10.1021/jm00032a007

Source and publish data:

Journal of Medicinal Chemistry p. 745 - 757 (1994)

Update date:2022-08-04

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Authors:

Zhang, Weijiang

Koehler, Konrad F.

Harris, Bradford

Skolnick, Phil

Cook, James M.

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Article abstract of DOI:10.1021/jm00032a007

The synthesis and in vitro evaluation of benzo-fused benzodiazepines 1-6 are described.These "molecular yardsticks" were employed to probe the spatial dimensions of the lipophilic pocket L₂ in the benzodiazepine receptor (BzR) cleft and to dete

Full text of DOI:10.1021/jm00032a007

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Article Doi

Synthesis of Benzo-Fused Benzodiazepines Employed as Probes of the Agonist Pharmacophore of Benzodiazepine Receptors

DOI: 10.1021/jm00032a007

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jm00032a007

Full text of DOI:10.1021/jm00032a007

Products guided by the article

R&D Labs maybe for 153684-41-4

Relevant to this article

Diastereoselective epoxidation of dipeptide olefins

Synthesis of 4-amino/hydroxy-6-methylthio-1/2-(2',2'-diethoxyethyl)-1H/2H-pyrazolo[ 3,4-d]pyrimidines and their antiallergic activity

4,8-Diphosphathiophenetriptycenes

Palladium-Catalyzed Carbonylative Cyclization of o-Allylbenzyl Halides To Produce Benzo-Annulated Enol Lactones and/or Bicyclo<3.3.0>hept-3-en-6-ones. An Efficient Route to U-68,215

An Efficient Synthesis of Some 6-Substituted 4,8-Diaza-3,3,9,9-tetramethylundeca-2,10-dione Dioximes (Propylene Amine Oximes, PnAOs): Ligands for 99mTc Complexes Used in Structure Distribution Relationship (SDR) Studies

Reductive Electrophilic Substitution of Pyrogallol Derivatives: Synthesis of 2,3-Disubstituted Phenols

An Efficient Synthesis of Some 6-Substituted 4,8-Diaza-3,3,9,9-tetramethylundeca-2,10-dione Dioximes (Propylene Amine Oximes, PnAOs): Ligands for ^99mTc Complexes Used in Structure Distribution Relationship (SDR) Studies