Journal of Organic Chemistry p. 10901 - 10910 (2019)
Update date:2022-08-05
Topics:
Mishra, Manmath
De, Pinaki Bhusan
Pradhan, Sourav
Punniyamurthy, Tharmalingam
Aerobic copper(II)-catalyzed tandem ring opening and oxidative C-H alkylation of donor-acceptor cyclopropanes with bisaryl hydrazones is accomplished to produce tetrahydropyridazines, in which copper(II) plays dual role as a Lewis acid as well as redox catalyst. The reaction is stereospecific, and optically active cyclopropanes can be reacted with high optical purities (89-98% enantiomeric excess). The substrate scope, functional group tolerance, dual role of the copper(II) catalyst, and the use of air as an oxidant are the important practical features. A product bearing a 3-bromoaryl group can be subjected to Pd-catalyzed Suzuki coupling with boronic acid in high yield.
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Doi:10.1021/jo951783n
(1996)Doi:10.1021/ja00086a007
(1994)Doi:10.1016/j.dyepig.2013.12.017
(2014)Doi:10.1016/S0040-4020(01)85080-8
(1994)Doi:10.1080/00304948.2014.866469
(2014)Doi:10.1016/0008-6215(94)84246-9
(1994)