Bulletin of the Chemical Society of Japan p. 524 - 528 (1994)
Update date:2022-07-30
Topics:
Kawai, Yasushi
Tsujimoto, Munekazu
Kondo, Shin-ichi
Takanobe, Kousuke
Nakamura, Kaoru
Ohno, Atsuyoshi
Various β-keto esters have been reduced by one of β-keto ester reductases isolated from bakers' yeast.The corresponding β-hydroxy esters have been obtained in excellent enantiomeric and diastereomeric excesses, respectively.It has also ben elucidated that the reductase recognizes the stereochemistry not only at the β-carbon but also at the α-carbon affording one of the four possible diastereoisomers of α-substituted β-hydroxy esters predominantly.The stereoselectivity is excellent and chemical yields are moderate to good.
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