Large-Scale Synthesis of Bosentan Monohydrate
491
MS m/z (ESI): 550.0 [(MCH) ¡]; IR: 3626, 3439, 3093, 3064, 3045, 3013, 2962, 2906,
1
2870, 1580, 1557, 1454, 1171, 1083; H NMR (DMSO, 300 MHz): d 1.27 (s, 9H), 3.49
(m, 2H), 3.80 (s, 3H), 4.35 (m, 2H), 4.69 (brs, 1H), 6.70 (d, 1H), 6.82 (dd, 1H), 7.08 (m,
2H), 7.56 (d, 2H), 7.68 (dd, 1H), 8.31 (d, 2H), 9.10 (d, 2H), 11.36 (brs, 1H); 13C NMR
(DMSO, 300 MHz):d 30.8, 34.8, 55.9, 59.2, 68.6, 113.1, 116.1, 120.6, 121.8, 123.5,
123.6, 125.3, 129.0, 137.04, 145.8, 149.1, 151.3, 155.5, 156.1, 157.9, 161.4.
Acknowledgements
The authors are grateful to colleagues in the Analytical Research Department of APL
Research center, a division of Aurobindo Pharma Ltd, Hyderabad for their valuable con-
tribution to this work. The authors also thank the management for permission to publish
this work and gratefully acknowledge the Executive Editor, Professor J.-P. Anselme, for
his patience, corrections and continuous suggestions in writing this manuscript.
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