Tetrahedron Letters p. 4311 - 4314 (1994)
Update date:2022-08-02
Topics:
Reddy, M. P.
Hanna, N. B.
Farooqui, Firdous
We have developed methylamine/ammonia as a fast cleavage and deprotection reagent which effects complete cleavage of oligonucleotides from the solid support in 5 min at room temperature and complete deprotection in 5 min at 65 deg C.The problem of transamination side products formation, faced with the commonly used dCbz (10percent side product) upon treatment with methylamine/ammonia, has been sucessfully solved by the use of dCac (0.0percent side product).DMT dCac phosphoramidite-methylamine/ammonia system furnished oligonucleotides in equal or superior quality as compared to the other systems.
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Doi:10.1002/recl.19941130602
(1994)Doi:10.1021/jo00090a036
(1994)Doi:10.1039/c3dt52753k
(2014)Doi:10.1002/ejoc.201301301
(2014)Doi:10.1021/ol5005565
(2014)Doi:10.1039/c4cc07921c
(2014)