Tetrahedron Letters p. 6445 - 6448 (1994)
Update date:2022-08-03
Topics:
Berkowitz, David B.
Shen, Quanrong
Maeng, Jun-Ho
The synthesis of the (α,α-difluoroalkyl)phosphonate analogue of L- phosphoserine, 5, in a form appropriate for solid phase peptide synthesis, is reported. Two independent routes are described, starting from L-serine or (R)-isopropylideneglycerol. In each case, PCF2-C bond formation is achieved by triflate displacement with diethyl lithiodifluoromethylphosphonate.
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(1987)