ACS Catalysis
Research Article
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Scheme 7. Mesylate Competition Study
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reactions.
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In summary, this paper describes the development of Pd-
catalyzed intra- and intermolecular arylations using mesylates.
The intramolecular reactions are applied toward the synthesis
of heterocycles including dibenzofurans, carbazoles, and
indoles. The intermolecular arylations are efficient for the
coupling of azoles with electronically diverse mesylates.
Preliminary mechanistic studies are presented for both the
intra- and intermolecular arylations. However, more detailed
kinetic studies are needed to elucidate the mechanistic
intricacies of these transformations.
ASSOCIATED CONTENT
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AUTHOR INFORMATION
Corresponding Author
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Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
This work was supported by the NIH NIGMS (R15
GM107892), the American Chemical Society Petroleum
Research Fund (52224-UNI3), and St. Olaf College.
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dx.doi.org/10.1021/cs500587b | ACS Catal. 2014, 4, 2395−2401