10.1002/ejoc.201901728
European Journal of Organic Chemistry
COMMUNICATION
55, 7227-7230; e) Y. Li, F. Zhu, Z. Wang, X.-F. Wu, ACS Catal., 2016,
6, 5561-5564.
4
5
41
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[10] X.-F. Wu, Chem. Eur. J. 2015, 21, 12252-12265.
aReaction conditions: 1a (0.4 mmol, 1.0 equiv), Mn(acac)2 (0.01
mmol), DTBP (0.6 mmol, 1.5 equiv), and HOAc (66 uL, 3.0
equiv) in PhCF3 (2 mL) at 140 °C for 20 h under CO (50 bar),
isolated yield.
In conclusion, we have developed a new carbonylative
protocol for the acetylation of heterocycles. With peroxide as the
methyl source, the desired methyl heterocyclic ketone products
were obtained in moderate to good yields with complete
chemoselectivity.
Acknowledgements
The authors thank the Chinese Scholarship Council for financial
support. The analytical supports from Dr. W. Baumann, Dr. C.
Fischer, S. Buchholz, and S. Schareina (all in LIKAT) are
gratefully acknowledged.
Keywords: Carbonylation • Radical • Acetylation • Ketones •
Coupling
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