Organic and Biomolecular Chemistry p. 5427 - 5434 (2014)
Update date:2022-08-05
Topics:
Du, Xiu-Jiang
Bian, Qiang
Wang, Hong-Xue
Yu, Shu-Jing
Kou, Jun-Jie
Wang, Zhi-Peng
Li, Zheng-Ming
Zhao, Wei-Guang
Carboxylic acid amide (CAA) fungicides are an important class of agricultural fungicide with oomycete activity and low toxicity toward mammalian cells. To find CAA analogues with high activity against resistant pathogens, a series of substituted N-benzhydryl valinamide carbamate derivatives were designed and synthesized by introducing substituted aromatic rings into valinamide carbamate leads. Bioassays showed that some title compounds exhibited very good in vitro fungicidal activity against Phytophthora capsici and in vivo fungicidal activities against Pseudoperonospora cubensis. Topomer CoMFA was performed to explore the structure-activity relationship on the basis of the in vitro data. The dimethoxy substituted aromatic analogue 9e was found to display higher in vitro fungicidal activity against Phytophthora capsici than iprovalicarb but lower activity than mandipropamid, and higher in vivo fungicidal activity against Pseudoperonospora cubensis than dimethomorph at a dosage of 6.25 μg mL-1. This journal is the Partner Organisations 2014.
View MoreGolden Union Agrochemical Import and Export Co., Ltd.
Contact:86-755-23910527
Address:Room 1106, Tower 3A, Excellence Century Center, Futian District, Shenzhen, China
Tianjin Realet Chemical Technology Co.,Ltd.
website:http://www.realetchem.com
Contact:+86-022-58788819
Address:shuanggang industrial park
Zhejiang PRIMAR Import & Export Trade Co., Ltd.
Contact:86-570-3630818
Address:No.1Puzhuyuan,Quhua,Zhejiang Province,China324004
Suzhou SuKaiLu Chemical Technology Co., Ltd.
Contact:+86-512-62766020
Address:Floor 4, Building 1, Xinyi Pharmaceutical Valley Wisdom Industrial Park, 415 Changyang Street, Suzhou Industrial Park, Jiangsu Province
Wuhan Sunrise Pharmaceutical Technology Co., Ltd
Contact:+86-27-83314682
Address:Room 340, New material Industrial base No.17, Gu Tian Five Lu , Qiaokou District, Wuhan , China
Doi:10.1039/c8cc08759h
(2019)Doi:10.1021/acs.joc.6b01990
(2016)Doi:10.1002/ejoc.201402260
(2014)Doi:10.1016/j.bmcl.2014.07.011
(2014)Doi:10.1021/acs.jmedchem.0c00567
(2020)Doi:10.1016/S0040-4039(00)71221-4
(1991)