Organic Process Research and Development p. 1405 - 1419 (2020)
Update date:2022-08-15
Topics:
Baenziger, Markus
Baierl, Marcel
Devanathan, Krishnaswamy
Eswaran, Sumesh
Fu, Peng
Gschwend, Bjoern
Haller, Michael
Kasinathan, Gopu
Kovacic, Nikola
Langlois, Audrey
Li, Yongfeng
Schuerch, Friedrich
Shen, Xiaodong
Wan, Yinbo
Wickendick, Regina
Xie, Siwei
Zhang, Kai
The development of the synthetic process to the selective estrogen receptor degrader (SERD) drug candidate LSZ102 from the medicinal chemistry synthesis to the streamlined large-scale manufacturing route is described. The synthesis of LSZ102 could be sign
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