Tetrahedron p. 1903 - 1920 (1995)
Update date:2022-08-03
Topics:
Okano, Takashi
Takakura, Nobuyuki
Nakano, Yuko
Okajima, Asako
Eguchi, Shoji
Various alkyl radicals generated by the photoreaction of a series of Barton esters reacted with 1,1-dichloro-2,2-difluoroethene to give radical adducts as the major product accompanied with self-trapping products. Primary, secondary, tertiary, benzyl, and some unsaturated alkyl radicals as well as those with another functional group such as ether, carbonyl, and azide were applicable. Barton esters of diacids also afford 1:2 adducts with a small amount of 1:1 adducts and bis-self-trapping products except for the succinic case. These adducts were hydrolyzed with AgNO3/H2O-THF to α,α-difluoroalkanecarboxylic acids and methanolyzed with AgNO3/MeOH to the corresponding methyl esters. 4-Azido-2,2-difluorobutylic acid and the methyl ester were converted to difluoro-GABA and difluoro-γ-lactams.
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Doi:10.1016/0277-5387(94)00328-C
(1995)Doi:10.1021/ma0205111
(2003)Doi:10.1055/s-0033-1341072
(2014)Doi:10.14233/ajchem.2014.15893
(2014)Doi:10.1039/c4ra02814g
(2014)Doi:10.1021/jm00011a002
(1995)