D
H. Sharghi, M. Aberi
LETTER
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Table 3 One-Pot Synthesis of 2H-Indazole Derivatives Using 2-
Chlorobenzaldehyde, Amines and NaN3 in the Presence of Cu2O-NP
in PEG at 170 °C
Entry
Amine
Product
Yield (%)a
1
2a
2b
2c
2d
2e
2f
4a
4b
4c
4d
4e
4f
79
80
85
87
83
89
88
67
74
82
80
84
81
2
3
4
5
6
7
2g
2h
2i
4g
4h
4i
8
9
10
2j
4j
11
2k
2l
4k
4l
12
13
2m
4m
a Isolated yield.
Acknowledgment
(11) Tang, B. X.; Wang, F.; Li, J. H.; Xie, Y. X.; Zhang, M. B.
J. Org. Chem. 2007, 72, 6294.
(12) Xu, H. J.; Zhao, X. Y.; Deng, J.; Fu, Y.; Feng, Y. S.
Tetrahedron Lett. 2009, 50, 434.
We gratefully acknowledge the support of this work by the Shiraz
University Research Council. We are also grateful to Mr. H. Sajedian
Fard and Mr. M. S. Darvish Tafvizi for their cooperation.
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49, 4556.
(15) Qu, Y.; Pan, L.; Wu, Z.; Zhou, X. Tetrahedron 2013, 69,
1717.
Supporting Information for this article is available online at
m
iotSrat
ungIifoop
r
t
(16) Wang, J. H.; Pan, C. W.; Li, Y. T.; Meng, F. F.; Zhou, H. G.;
Yang, C.; Zhang, Q.; Bai, C. G.; Chen, Y. Tetrahedron Lett.
2013, 54, 3406.
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(20) General Procedure: To a mixture of 2-bromobenzaldehyde
(1.0 mmol) or 2-chlorobenzaldehyde (1.0 mmol), amine (1.1
Synlett 2014, 25, A–E
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