Tetrahedron Letters p. 9309 - 9312 (1999)
Update date:2022-08-03
Topics:
Catasus, Monica
Moyano, Albert
Pericas, Miquel A.
Riera, Antoni
A new approach to the synthesis of N-methyl-γ-amino-β-hydroxy acids, compounds that are essential components of several depsipeptides exhibiting highly interesting therapeutic profiles, is presented. Relevant steps in the synthetic sequence involve the totally stereoselective preparation of a protected aminoalkyl epoxide from a highly enantiopure 2,3-epoxy alcohol, efficient N-methylation and three-step conversion to the desired N-methyl amino acid. The method is exemplified by the enantioselective synthesis of (3R,4S)-4-(N-methylamino)-3-hydroxy-5-phenylpentanoic acid in two differently protected forms.
View MoreContact:+86-27-85733560
Address:NO.308,QINGNIAN RD.,WUHAN,CHINA
Shandong Shouguang Songchuan Industrial Additives Co.,Ltd
Contact:+86-536-8566856
Address:Shouguang,Shandong,China
Quzhou Ruiyuan chemical Co., Ltd
Contact:+86-570-3039321/3039361/3039308
Address:18# Huayang Road,Quzhou High-tech Industrial Park, Zhejiang China.
Hangzhou Ocean Chemical Co., Ltd.
website:http://www.hzoceanchem.com
Contact:+86-571-88025872, 28272092, 28272096
Address:Room 623 ,Building No 1 , COFCO Radius Commercial Center Xiwen Road, Xiacheng District, Hangzhou, Zhejiang Province, China
Contact:+86-(0)21-3770 9035
Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
Doi:10.1002/jhet.2008
(2014)Doi:10.1021/acs.joc.0c00150
(2020)Doi:10.1021/jo00121a027
(1995)Doi:10.1007/s10600-012-0253-x
(2012)Doi:10.1021/ol0353159
(2003)Doi:10.1039/DT9950001645
(1995)