Journal of Medicinal Chemistry p. 4131 - 4134 (1995)
Update date:2022-07-29
Topics:
Kelley
Koble
Davis
McLean
Soroko
Cooper
A series of (fluorobenzyl)triazolo[4,5-c]pyridines was synthesized and tested for activity against maximal electroshock-induced seizures in rodents. The most promising compound, 14 (BW 534U87), which is a carbon-nitrogen isoster of a purine anticonvulsant, has a profile in rodents that suggests 14 will be free of emesis and useful in the treatment of seizure disorders for which phenytoin is presently indicated.
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(1995)Doi:10.1039/P19950002487
(1995)