Journal of Fluorine Chemistry p. 41 - 46 (1995)
Update date:2022-09-26
Topics:
Nishiwaki, Tarozaemon
Kikukawa, Hirofumi
Kawaji, Takatoshi
2-Aryl-3-arylamino-4,4,4-trifluoro-2-butenitriles were obtained as hydrates from 3-oxo-2-aryl-4,4,4-trifluorobutyronitriles and anilines and their structure and heterocyclizations studied.Cyclization with polyphosphoric acid gave poor yields of 3-aryl-2-trifluoromethyl-4-quinolones, but they underwent an interesting cyclization with diazomethane to give a 25percent-40percent yield of 4-N-methylamino-3H-pyrazole-3-spiro-2'-(3'-aryl-3'-trifluoromethyl)oxiranes.However, the related reaction with diazoethane yielded anly aryl(arylhydrazono)acetonitriles and other fragmentation products. - Keywords: Heterocyclizations; Fluorinated oxiranes; NMR spectroscopy; IR spectroscopy; UV spectrophotometry
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