Tetrahedron p. 11547 - 11556 (1995)
Update date:2022-09-26
Topics:
Barlocco, Daniela
Villa, Stefania
Fratta, Walter
Fadda, Paola
Colombo, Diego
Toma, Lucio
Several monocyclic derivatives structurally related to the μ-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo<3.2.1>octane have been synthesized and tested in binding studies using the μ-selective 3H-DAMGO as ligand.Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards μ-opioid receptors.
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Doi:10.1021/jacs.9b07019
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