Organic Letters
Letter
Table 3. Rh-Catalyzed Asymmetric Hydrogenation of α-CF3-
enamides
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a
Unless otherwise mentioned, all reactions were carried out with a
substrate/catalyst ratio of 100:1 in MeOH at room temperature under
5 atm hydrogen pressure for 6 h. The yield of the isolated product
based on consumed starting material. Determined by chiral HPLC
analysis. 0.1 mol % of catalysis, 10 atm, 12 h.
b
c
d
strategy will provide a novel way for making chiral α-
trifluoromethylated amines. Further investigations on asym-
metric hydrogenation of functionalized enamides are underway
in our laboratory.
ASSOCIATED CONTENT
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S
* Supporting Information
Experimental details and characterization data. This material is
AUTHOR INFORMATION
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Corresponding Authors
Notes
(11) Yokoyama, Y.; Mochida, K. Synlett 1996, 5, 445−446.
(12) The absolute configuration is identified by comparison of the
optical rotation of 3a with that reported in the literature: Fustero, S.;
The authors declare no competing financial interest.
Pozo, C.; Catalan
Lett. 2009, 11, 641−644.
́
, S.; Aleman
́
, J.; Parra, A.; Marcos, V.; Ruano, J. Org.
ACKNOWLEDGMENTS
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We are grateful for financial support by a grant from Wuhan
University (203273463), Natural Science Foundation of Hubei
Province (2014CFB181), “111” Project of the Ministry of
Education of China, and the National Natural Science
Foundation of China (Grant No. 21372179, 21432007).
C
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