Journal of Medicinal Chemistry p. 908 - 913 (1982)
Update date:2022-09-26
Topics:
Kline, Toni B.
Benington, Frederick
Morin, Richard D.
Beaton, John M.
A series of N,N-dialkyltryptamines with methylthio or methylenedioxy substituents in the 4, 5, and 6 positions and methyl or isopropyl on the side-chain nitrogen has been synthesized.The behavioral pharmacology of these compounds showed them to posses Bovet-Gatti profiles characteristic of hallucinogens, and the 5-methylthio congener was the most potent.Binding studies at <3H>LSD and <3H>5-HT sites demonstrated that no single structural feature correlated with binding or behavioral changes and suggest a complex mode of action for these potential hallucinogenic agents.
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