Bioorganic and Medicinal Chemistry Letters p. 1137 - 1139 (2003)
Update date:2022-08-05
Topics:
Penning, Thomas D.
Chandrakumar, Nizal S.
Desai, Bipin N.
Djuric, Stevan W.
Gasiecki, Alan F.
Malecha, James W.
Miyashiro, Julie M.
Russell, Mark A.
Askonas, Leslie J.
Gierse, James K.
Harding, Elizabeth I.
Highkin, Maureen K.
Kachur, James F.
Kim, Suzanne H.
Villani-Price, Doreen
Pyla, E. Yvonne
Ghoreishi-Haack, Nayereh S.
Smith, Walter G.
The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA4 hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excellent potency in our in vitro assays, as well as good oral activity in a mouse ex vivo assay.
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