Nucleosides, nucleotides and nucleic acids p. 1497 - 1522 (2001)
Update date:2022-08-05
Topics:
Rejman
Masojidkova
De Clercq
Rosenberg
A series of novel, unusual type of acyclic phosphonate-based nucleotide analogues related to well-known antivirals (PMEA and HPMPA) was synthesized using easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives that contribute to the understanding of structure-activity relationship within the area of acyclic nucleotide analogues.
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