Synlett p. 83 - 84 (1997)
Update date:2022-08-02
Topics:
Ojea, Vicente
Ruiz, María
Quintela, José M.
(+)-D-fucosamine and (+)-N-methyl-D-fucosamine (the amino sugar moiety of neocarzinostatin) have been synthesized from known building blocks derived from natural amino acids. Direct and diastereoselective construction of the key intermediate 4 was accomplished by a syn-aldol type reaction between Sch?llkopf's bislactim ether 2 and the 1,3-dioxolane-4-carboxaldehyde 3. Reduction and monomethylation of a O'Donnell's Schiff base derived from the common amino ester 7 allows an optional access to the N-methyl derivative.
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Doi:10.1248/cpb.45.75
(1997)Doi:10.1055/s-1996-4412
(1996)Doi:10.1021/jo9622791
(1997)Doi:10.1021/ja9631256
(1997)Doi:10.1002/anie.201607355
(2016)Doi:10.1021/ja01611a086
(1955)