Tetrahedron Letters p. 2887 - 2890 (1996)
Update date:2022-07-31
Topics:
Hutchison, Darrell R.
Nayyar, Naresh K.
Martinelli, Michael J.
A general synthesis of 4-keto-4,5,6,7-tetrahydroindoles 6-12 has been achieved in two steps using a new intramolecular 1,3-dipolar cycloaddition approach in moderate yields (45-60%). The potential of this methodology is demonstrated by the synthesis of a mitomycin skeleton (15) and a topoisomerase-1 inhibitor skeleton (17).
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