8748
J.-R. Che´rou6rier et al. / Tetrahedron Letters 43 (2002) 8745–8749
Table 2. Preparation of methyl 4-[(1-alkyl-5-oxo-2-thioxo-imidazolidin-4-ylidenemethyl)-amino]acetate 12(a,b) and butanoate
12(c,d) from 3(a,b) and aminoesters 11(a,b)
Aminoester 11
n
Product 12
R1
Reaction conditionsa
Yield of 12 (%)b
Time (h)
Temp. (°C)
11a
11a
11b
11b
0
0
2
2
12a
12b
12c
12d
Me
Bu
Me
Bu
1.5
1.5
1.5
1.5
95
95
95
95
16
47
40
30
a The reactions were performed under microwave irradiations in the Synthewave® 402 reactor.
b Isolated yield.
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