Tetrahedron Letters p. 1363 - 1366 (1997)
Update date:2022-08-03
Topics:
Gabriel, Tobias
Wessjohann, Ludger
In a two step, one pot reaction of 4-benzyl oxazolidinone, 2-bromoacetyl halide, chromium dichloride and a suitable 3-oxo-aldehyde derivative the C1-C6-Me-fragment of epothilons is available in its correct oxidation state and enantiomeric form. Compared to common methods, the chromium-Reformatsky variation preferentially yields the opposite diastereomers and gives improved chemo- and diastereoselection.
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