Journal of Antibiotics p. 237 - 245 (1997)
Update date:2022-08-02
Topics:
Clear, Nicola J. C.
Davies, John S.
Eglington, A. John
Fell, Stephen C. M.
Hinks, Jeremy D.
Hird, Nicholas W.
Hunt, Eric
Moss, Stephen F.
Pearson, Michael J.
The synthesis, antibacterial activity and stability to human dehydropeptidase-1 (DHP-1) of three small series of carbapenems carrying carbon-linked substituents at C-2 are described. C-2 Ethenyl carbapenems showed moderate antibacterial activity but poor stability to DHP-1. C-2 Oxyiminomethyl carbapenems demonstrated variable activity and stability. C-2 α-(Hydroxy)benzyl carbapenems were the most promising and showed good potency and DHP-1 stability.
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Doi:10.1021/jo9901790
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(1997)Doi:10.1016/S0960-894X(97)00090-5
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(1998)Doi:10.1021/jm9800752
(1998)Doi:10.1039/a607709i
(1997)