Bioorganic and Medicinal Chemistry Letters p. 77 - 80 (2002)
Update date:2022-08-05
Topics:
Miyachi, Hiroyuki
Nomura, Masahiro
Tanase, Takahiro
Takahashi, Yukie
Ide, Tomohiro
Tsunoda, Masaki
Murakami, Koji
Awano, Katsuya
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
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