Bulletin of the Chemical Society of Japan p. 1441 - 1450 (1997)
Update date:2022-08-03
Topics:
Liu, Wen-Chi
Oikawa, Masato
Fukase, Koichi
Suda, Yasuo
Winarno, Hendig
Mori, Saeko
Hashimoto, Masahito
Kusumoto, Shoichi
Synthesis of unnatural analogues, that contain (S)-3-hydroxytetradecanoyl moieties in place of the corresponding natural (R)-isomers, of both lipid A and its biosynthetic precursor, designated precursor Ia or lipid IV(A), has been achieved through our recently developed procedure. (S)-3-Hydroxytetradecanoic acid was prepared from its racemate through the optical resolution by the use of a lipase and subsequent fractional recrystallization. The (S)-acyl analogue of lipid A exhibited slightly stronger interleukin-6 inducing activity than the corresponding natural lipid A, and the (S)-acyl analogue of the biosynthetic precursor was far more active than the natural precursor in inhibiting the induction of interleukin-6 by lipopolysaccharide.
View Morewebsite:http://www.finetechnology-ind.com
Contact:86-27-87465837
Address:wuhan
Weifang Jahwa Chemical Co.,Ltd
Contact:0086-536-8897731,8897730
Address:No.5166 East Dongfeng Street,Weifang,Shandong,China
Beijing Merson Pharmaceutical Co., Ltd
Contact:0086-10-80484934 0086-10-80484574/
Address:2nd Floor , No. 2 Building , No. 14 Houshayu Duan, Jingmi Road ,Shunyi District , Beijing 101318, P.R.China
Beijing Apis Biotechnology Co., Ltd.
Contact:86-010-67856775-8551
Address:NO.4PUHUANGYU ROAD,FENTAI DISTRICT, BEIJING, CHINA
Wuxi D-Stone International Co., Ltd.
Contact:+86-510-82740567
Address:21F Hengtong Int'l Centre, 215Zhongshan Road, Wuxi, Jiangsu,China
Doi:10.1021/ja970108n
(1997)Doi:10.1002/ejoc.200800213
(2008)Doi:10.1021/ja970502l
(1997)Doi:10.1016/S0960-894X(03)00102-1
(2003)Doi:10.1007/s00044-009-9277-6
(2011)Doi:10.1021/ja01016a071
(1968)