Journal of labelled compounds and radiopharmaceuticals p. 541 - 557 (1997)
Update date:2022-07-30
Topics:
Schneider
Engelhardt
Stobbe
Fenning
Chapman
Seven second-generation hypoxic markers of the iodinated azomycin nucleoside class have been synthesized and tested for hypoxia marking activity with tumor cells in vitro and in vivo. β-D-lodoazomycin galactoside (IAZG) and β-D-lodoazomycin xylopyranoside (IAZXP) demonstrated superior hypoxia marking properties relative to IAZA because of their higher water solubilities, rapid plasma clearance rates from tumor-bearing mice and maximum tumor/blood (T/B) and tumor/muscle (T/M) ratios. Our studies with animal tumor models show that T/B or T/M ratios of these markers determined by scintigraphy or planar imaging can predict for the relative degree of tumor hypoxia and for tumor radioresistance.
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Doi:10.1002/jhet.5570340303
(1997)Doi:10.1139/v97-095
(1997)Doi:10.1016/S0040-4039(97)01130-1
(1997)Doi:10.1021/ja971037v
(1997)Doi:10.1016/S0960-894X(97)00309-0
(1997)Doi:10.1021/jo970173f
(1997)