Bioorganic and Medicinal Chemistry Letters p. 81 - 86 (1996)
Update date:2022-08-05
Topics:
Sall, Daniel J.
Arfsten, Ann E.
Berry, Dennis R.
Denney, Michael L.
Harms, Cathy S.
McCowan, Jefferson R.
Ray, Judith K.
Scarborough, Robert M.
Um, Suzane L.
Utterback, Barbara G.
Jakubowski, Joseph A.
A series of substituted amidinoindoles have been prepared as mimics of the RGD sequence and were studied as antagonists of the platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa). The agents were potent and selective antagonists of GPIIb-IIIa. Compared to their acyclic counterparts, the amidinoindole series bound with 10- to 20-fold greater affinity, indicating the advantages of added conformational restriction and/or hydrophobicity in the basic region of RGD mimics.
View MoreShenzhen JYMed Technology Co.,Ltd.
website:http://www.jymedtech.com
Contact:+86-755-26612112
Address:RM1-105, Shenzhen Bio-incubator Base, 10 Gaoxin C Avc 1st, Nanshan District, Shenzhen, GD, China, 518057
Nanjing Vincero International Trading Co.,Ltd
Contact:8618936897229
Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Shanghai Bocimed Pharmaceutical Co., Ltd.
website:http://www.bocimed.com
Contact:+86-21-68861632
Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
Liaoyang Xinyou Chemical Products Co.,Ltd.
Contact:+86-419-5165433 13604191870
Address:Huishang Road6-1, Hongwei District, Liaoyang, Liaoning, China
WUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.
Contact:13861062998
Address:Room 1316,No.1619 Huishan Avenue,Wuxi,China
Doi:10.1016/j.tet.2013.03.071
(2013)Doi:10.1007/BF02495407
(1997)Doi:10.7164/antibiotics.50.586
(1997)Doi:10.1021/ja962465o
(1997)Doi:10.1021/jo971027c
(1997)Doi:10.1016/S0040-4039(97)01262-8
(1997)