Bioorganic and Medicinal Chemistry p. 1489 - 1495 (1997)
Update date:2022-08-03
Topics:
Ohno, Nobuhiro
Fukamiya, Narihiko
Okano, Masayoshi
Tagahara, Kiyoshi
Lee, Kuo-Hsiung
The C-15 senecioyl side chain of brusatol was interchanged with fluorinated acyl groups, and the C-3 hydroxy group of bruceolide was esterified with fluorinated acyl chlorides. These fluorinated quassinoids 11, 12, 13, and 17 showed significant cytotoxic activity against eight human cancer cell lines including small and non-small cell lung, colon, CNS, ovarian and renal cancers, leukemia, and melanoma with 17 being about 100 times more potent than 11, 12, and 13. The activity of 17 was similar to that of bruceantin (1) in this in vitro cell line panel.
View MoreShanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
ChangZhou XiaQing Chemical Co., Ltd.
Contact:+86-519-88721665
Address:3# Hengluo Road, Henglin Town, Changzhou City, Jiangsu Province,China
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
Wuhan Better Organic Technology Inc.
Contact:13307163183
Address:Wuhan Economic&Technology Development Zone, Hubei
JIAXING SUNS INTERNATIONAL TRADE CO LTD
Contact:18367306858
Address:No.123,Huixin Avenue,Huimin Dist
Doi:10.1016/j.carbpol.2018.07.089
(2018)Doi:10.1021/jo0258406
(2002)Doi:10.1002/jlcr.2580150153
(1978)Doi:10.1016/S0008-6215(00)86061-9
(1979)Doi:10.1016/S0040-4039(02)00067-9
(2002)Doi:10.1016/j.ejmech.2020.112411
(2020)