Journal of Heterocyclic Chemistry p. 1147 - 1151 (1997)
Update date:2022-09-26
Topics:
Troschuetz, Reinhard
Karger, Alexander
The synthesis of 6-phenyl-atevirdine (17), a lipophilic derivative of the potent HIV-1 reverse transcriptase inhibitor atevirdine (1), is described. The title compound was prepared from dithioacetale 2 via keteneaminal 4 and the nitropyridine derivative 10. Unexpectedly, no anti HIV activity was observed for the novel atevirdine derivative 17. The key intermediates 6, 8 and 10 could also be prepared from keteneaminal 18 via chloropyridines 22-24.
View MoreZhuzhou Farshine Chemical Industry Co., Ltd
Contact:0086-731-28482786
Address:No. 1,Shui Xian Road, He Tang Dictrict,Hunan-412000,China
Compro Shijiazhuang Fine Chemical Co., Ltd
Contact:0086-311-89689838
Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Contact:+86-579-85206992
Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
website:http://www.enbridgepharm.com
Contact:+86-510-83591909
Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China
Contact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
Doi:10.1039/j39680001274
(1968)Doi:10.1016/S0040-4039(01)98819-7
(1968)Doi:10.1080/00397911.2011.579382
(2012)Doi:10.1016/S0277-5387(97)00154-X
(1997)Doi:10.1016/j.tet.2011.12.077
(2012)Doi:10.1149/1.2095953
(1988)