Synthesis p. 1411 - 1414 (1997)
Update date:2022-07-31
Topics:
Kowalczyk, Bruce A.
A simple synthetic strategy to dihalophenylacetic acids and specifically 3,5-difluorophenylacetic acid an important pharmaceutical intermediate was developed. The aromatic nucleophilic substitution of dihalofluorobenzenes using the anion of ethyl cyanoacetate yielded ethyl dihalophenylcyanoacetates. The basic decarboxylation of the ethyl dihalophenylcyanoacetates produced targeted dihalophenylacetic acids.
View MoreContact:+86-0592 5353131
Address:No.56 Guani Road Software Park 2,Siming District
LIAONING DMSO CHEMICALS CO.,LTD.
website:http://www.chinadmso.com
Contact:+86-427-6503033
Address:FLOOR 16, BLOCK A, FINANCIAL SQUARE, XINGLONGTAI DISTRICT, PANJIN CITY, LIAONING P.R. CHINA
Jiangsu Jiuri Chemical Co.,Ltd.
Contact:+86-519-82118868
Address:Tianwang Town, Jurong City, Jiangsu Province, China
Xuzhou Tianrun Chemical Co.,Ltd
website:http://www.tianrunchem.cn
Contact:86-516-83832636
Address:fuxing road
Jiangsu Wanlong Chemical Co., Ltd.
website:http://www.wanlongchem.com
Contact:+86-511-86810993 0086-511-8681 0888;
Address:Quanzhou Town, Danyang City, Jiangsu
Doi:10.1007/BF02495774
(2000)Doi:10.1016/j.bmc.2015.07.071
(2015)Doi:10.1246/bcsj.71.433
(1998)Doi:10.1021/jo9716845
(1998)Doi:10.1248/cpb.46.79
(1998)Doi:10.1002/(sici)1521-3749(199803)624:3<399::aid-zaac399>3.0.co;2-7
(1998)