Tetrahedron Letters p. 313 - 316 (1998)
Update date:2022-08-03
Topics:
Nakada, Masahisa
Kojima, Ei-Ichi
Iwata, Yukitaka
A concise synthetic approach to an optically active taxol C-ring fragment starting from a readily available compound is described. Lewis acid promoted-cyclization of optically active epoxy trimethylsilane 7 affords the key intermediate 8 in 69% yield (at 91% conversion). Further transformation of 8 to our taxol C-ring fragment is successfully achieved in a stereoselective manner.
View MoreContact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Zhuhai Rundu Pharmaceutical co.,Ltd
Contact:+86-756-7630755
Address:No.6,North Airport Road,Sanzao Town,Jinwan District
Contact:.+86-579-85566777
Address:12222222222dsadsdsdeeeee
Tianjin Pharmacn Medical Technology Co.,Ltd.
Contact:86-22-60122566ext.866(English),23359620
Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Lyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Doi:10.1016/S0040-4039(97)10613-X
(1998)Doi:10.1080/07328309808005766
(1998)Doi:10.1021/ol1004643
(2010)Doi:10.1016/j.tetlet.2018.01.012
(2018)Doi:10.1248/cpb.12.749
(1964)Doi:10.1039/a706293a
(1998)