Communication
Green Chemistry
Then the nucleophilic C3 position of indole triggers spirocycli-
zation to afford the desired product 3aa.
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Conclusions
In conclusion, a new approach for Co-catalyzed coupling of
tryptamine-derived isocyanides with sulfonyl azides in water to
construct spiroindolenine derivatives has been successfully
demonstrated. Instead of column chromatography used for
most work-up processes, purification of the products in our
case can be realized simply by sequential operation involving
extraction, concentration, precipitation, and filtration. This
strategy features mild reaction conditions, high atom
economy, excellent yields, wide substrate scopes, and broad
functional group tolerance. More importantly, the aqueous
catalytic system could be recycled at least ten times without a
visible decrease of catalytic activity. The strategy is in line with
the new green chemistry concept, and it may have a potential
application in industrial production. From the N-sulfonyl
amidine skeleton point of view, the product can also serve as a
potential intermediate for diverse organic syntheses.10
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Conflicts of interest
There are no conflicts to declare.
Acknowledgements
We gratefully acknowledge the National Natural Science
Foundation of China (No. 21772138, 21672157), the Project of
Scientific and Technologic Infrastructure of Suzhou
(SZS201708) and PAPD. We thank Rui-Ying Zhang in our group
for reproducing the results of 3ak, 3ia and 3la, and the recycl-
ability and reusability of the cobalt catalyst in the water phase.
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2622 | Green Chem., 2021, 23, 2619–2623
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