Tetrahedron p. 3479 - 3488 (1998)
Update date:2022-09-26
Topics:
Kardassis, Georgios
Brungs, Peter
Nothhelfer, Christoph
Steckhan, Eberhard
Chiral 3-methoxy-2,5-morpholinediones which are cyclic N,O-acetals have proved to be excellent chiral cationic amino acid equivalents, especially if larger nucleophiles are employed. They are easily obtained from dipeptolides formed between chiral α-hydroxy acids and dimethyl amino malonate via regioselective electrochemical methoxylation followed by intramolecular lactonizatian after decarboxylation. The lactonization can be performed quantitatively from the open-chain peptolide by condenzation under reduced pressure at elevated temperature. The easy separation of the desired amino acid and the α-hydroxy acid being the chiral auxiliary by extraction is valuable.
View MoreJinTan Pingsheng Chemical Co.,Ltd
Contact:+86-519-82828200
Address:NO.11Danfengxilu Road,Jintan City,Jiangsu,China
shanghai hekang chemical co.ltd
Contact:021-54173790
Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
Beijing Mediking Biopharm Co., Ltd.
Contact:+86-10-89753524/81760121/81769521
Address:Hongxianghong Incubator, Beiqijia Town, Changping district, Beijing, China
Lanzhou huibang biological chemical technology Co., LTD
Contact:0931-7843964
Address:NO.2011,Yannan Road,Chengguan,
Zhejiang Rongkai Chemical Technology Co.,Ltd.
Contact:+86-578-8185786
Address:Shangjiang Industrial Zone,Suichang
Doi:10.1246/bcsj.49.2518
(1976)Doi:10.1021/ja01099a036
(1953)Doi:10.1021/ic971534c
(1998)Doi:10.1016/j.molcata.2014.02.017
(2014)Doi:10.1021/ja980052c
(1998)Doi:10.1016/S0040-4039(00)91166-3
(1975)