Journal of Heterocyclic Chemistry p. 1511 - 1519 (2000)
Update date:2022-09-26
Topics:
Lopez
Quijano
Sanchez
Nogueras
Reactions between 5,6-diaminopyrimidines 1a-c and pentoses 2a-e yield 5-N-glycosylaminopyrimidines or 7-polyhydroxyalkylpteridines, depending on the presence or absence of acetic acid. The "in vitro" anti-HIV activity of 6-amino-2-methoxy-3-methyl-5-N-D-ribosylaminopyrimidin-4(3H)-one 3e, 6-amino-2-methoxy-3-methyl-5-N-β-D-xylopyranosylaminopyrimidin-4(3H)-one 3f, and 6-amino-2-methylthio-5-N-β-L-xylopyranosylminopyrimidin-4(3H)-one 3k, appears to be promising.
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