Nucleosides and Nucleotides p. 1473 - 1487 (1998)
Update date:2022-07-29
Topics:
Jeong, Lak Shin
Lee, Young A.
Moon, Hyung Ryong
Chun, Moon Woo
Novel apio dideoxynucleosides with azido or amino substituent were synthesized starting from 1,3-dihydroxyacetone utilizing an acid-catalyzed 1,4conjugated addition as a key step and evaluated for antiviral activity. Unfortunately, they were found to be neither active against HIV-1, HSV-1,2 and poliovirus nor toxic.
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