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creases Hippocampal BDNF Protein Levels: Implications for Stressꢀ
Related Psychiatric Disorders. Neuropsychopharmacology 2006, 31,
1112ꢀ1122.
21. Park, S.; Jung, S.W.; Kim, B.N.; Cho, S.C.; Shin, M.S.; Kim, J.W.;
Yoo, H.J.; Cho, D.Y.; Chung, U.S.; Son, J.W.; Kim, H.W. Associaꢀ
tion between GRM7 rs3792452 polymorphism and attentionꢀ
deficit/hyperactivity disorder in a Korean sample. Behav. Brain
Funct. 2013, 9, 1ꢀ11.
22. Kandaswamy, R.; McQuillin, A.; Curtis, D.; Gurling, H. Allelic assoꢀ
ciation, DNA resequencing and copy number variation at the metaboꢀ
tropic glutamate receptor GRM7 gene locus in bipolar disorder. Am. J.
Genet. B Neuropsychiatr. Genet. 2014, 165B, 365ꢀ372.
23. Liu, Y.; Zhang, Y.; Zhao, D.; Dong, R.; Yang, X.; Tammimies, K.;
Uddin, M.; Scherer, S.W.; Gai, Z. Rare de novo deletion of metaboꢀ
tropic glutamate receptor 7 (GRM7) gene in a patient with autism
spectrum disorder. Am. J. Genet. B Neuropsychiatr. Genet. 2015,
168B, 258ꢀ264.
1
2
3
4
5
6
7
8
8. Holscher, C.; Schmid, S.; Pilz, P.K.; Sansig, G.; van der Putten, H.;
Plappert, C.F. Lack of the metabotropic glutamate receptor subtype 7
selectively modulates Theta rhythm and working memory. Learn
Mem 2005, 12, 450ꢀ455.
9. Holscher, C.; Schmid, S.; Pilz, P.K.; Sansig, G.; van der Putten, H.;
Plappert, C.F. Lack of the metabotropic glutamate receptor subtype 7
selectively impairs shortꢀterm working memory but not longꢀterm
memory. Behav. Brain Res. 2004, 154, 473ꢀ481.
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
10. Bushell, T.J.; Sansig, G.; Collett, V.J.; van der Putten, H.;
Collingridge, G.L. Altered shortꢀterm synaptic plasticity in mice
lacking the metabotropic glutamate receptor mGlu7.
ScientificWorldJournal 2002, 2, 730ꢀ737.
24. Charng, W.L.; Karaca, E.; CobanꢀAkdemir, Z.; Gambin, T.; Atik,
M.M.; Gu, S.; Posey, J.E.; Jhangiani, J.A.; Muzny, D.M.; Doddapꢀ
aneni, H.; Hu, J.; Boerwinkle, E.; Gibbs, R.A.; Rosenfeld, J.A.; Cui,
H.; Xia, F.; Manickam, K.; Yang, Y.; Faqeih, E.A.; Al Asmari, A.;
Saleh, M.A.; ElꢀHattab, A.W.; Lupski, J.R. Exome sequencing in
mostly consanguineous Arab families with neurological disease proꢀ
vides a high potential molecular diagnosis rate. BMC Med. Genomics
2016, 19, 42ꢀ54.
25. Reuter, M.S.; Tawamie, H., et al. Diagnostic yield and novel candiꢀ
date genes by exome sequencing in 152 consanguineous families with
neurodevelopmental disorders. JAMA Psychiatry 2017, 74, 293ꢀ299.
26. Gogliotti R.G., Senter R.K. , Fisher N.M , Adams J. , Zamorano R. ,
Walker A.G., Blobaum A.L. , Engers D.W. , Hopkins C.R. , Daniels
J.S., Jones, C.K. , Lindsley C.W., Xiang Z., Conn P.J., and Niswender
C.M. Metabotropic Glutamate Receptor 7 Allosteric Modulation Resꢀ
cues Long Term Potentiation, Cognition and Apneas in Mecp2ꢀ
Deficient Mice. Sci. Trans. Med. 2017, 9, eaai7549.
27. JalanꢀSakrikar, N.; Field, J.R.; Klar, R.; Mattmann, M.E.; Gregory,
K.J.; Zamorano, R.; Engers, D.W.; Bollinger, S.R.; Weaver, C.D.;
Days, E.; Lewis, L.M.; Utley, T.J.; Hurtado, M.; Rigault, D.; Acher,
F.; Walker, A.G.; Melancon, B.J.; Wood, M.R.; Lindsley, C.W.;
Conn, P.J.; Xiang, Z.; Hopkins, C.R.; Niswender, C.M. Identification
of positive allosteric modulators VU0155094 (ML397) and
VU0422288 (ML396) reveals new insights into the biology of
metabotropic glutamate receptor 7. ACS Chem. Neurosci. 2014, 5,
1221ꢀ1237.
28. Le Poul, E.; Bolea, C.; Girarg, F.; Poli, S.; Charvin, D.; Campo, B.;
Bortoli, J.; Bessif, A.; Luo, B.; Koser, A.J.; Hodge, L.M.; Smith,
K.M.; DiLella, A.G.; Liverton, N.; Hess, F.; Browne, S.E.; Reynolds,
I.J. A potent and selective metabotropic glutamate receptor 4 positive
allosteric modulator improves movement in rodent models of Parksinꢀ
son’s disease. J. Pharmacol. Exp. Ther. 2012, 343, 167ꢀ177.
29. Kalinichev, M.; Rouillier, M.; Girard, F.; RoyerꢀUrios, I.; Bournique,
B.; Finn, T.; Charvin, D.; Campo, B.; Le Poul, E.; Mutel, V.; Poli, S.;
Neale, S.A.; Salt, T.E.; Lutjens, R. ADX71743, a potent and selective
negative allosteric modulator of metabotropic glutamare receptor 7: in
vitro and in vivo characterization. J. Pharmacol. Exp. Ther. 2013, 3,
624ꢀ636.
11. Masugi, M.; Yokoi, M.; Shigemoto, R.; Muguruma, K.; Watanabe,
Y.; Sansig, G.; van der Putten, H.; Nakanishi, S. Metabotropic glutaꢀ
mate receptor subtype 7 ablation causes deficit in fear response and
conditioned taste aversion. J. Neurosci. 1999, 19, 955ꢀ963.
12. Breen, G.; Webb, B.T.; Butler, A.W.; van den Oord, E.J.; Tozzi, F.;
Craddock, N.; Gill, M.; Korszun, A.; Maier, W.; Middleton, L.; Mors,
O.; Owen, M. J.; CohenꢀWoods, S.; Perry, J.; Galwey, N. W.; Upꢀ
manyu, R.; Craig, I.; Lewis, C. M.; Ng, M.; Brewster, S.; Preisig, M.;
Rietschel, M.; Jones, L.; Knight, J.; Rice, J.; Muglia, P.; Farmer, A.
E.; McGuffin, P. A genomeꢀwide significant linkage for severe deꢀ
pression on chromosome 3: the depression network study. Am. J. Psy-
chiatry 2011, 168, 840−847.
13. Ganda, C.; Schwab, S. G.; Amir, N.; Heriani, H.; Irmansyah, I.;
Kusumawardhani, A.; Nasrun, M.; Widyawati, I.; Maier, W.; Wildenꢀ
auer, D. B. A familyꢀbased association study of DNA sequence variꢀ
ants in GRM7 with schizophrenia in an Indonesian population. Int. J.
Neuropsychopharmacol. 2009, 12, 1283−1289.
14. Mick, E.; Neale, B.; Middleton, F. A.; McGough, J. J.; Faraone, S. V.
Genomeꢀwide association study of response to methylphenidate in
187 children with attentionꢀdeficit/hyperactivity disorder. Am. J. Med.
Genet., Part B 2008, 147B, 1412−1418.
15. Yang, Y. and Pan, C. Role of metabotropic glutamate receptor 7 in
autism spectrum disorders: a pilot study. Life Sci. 2013, 92, 149–153.
16. Elia, J.; Glessner, J.T., et al. Genomeꢀwide copy number variation
study associated metabotropic glutamate receptor gene networks with
attention deficit hyperactivity disorder. Nat. Genetics 2012, 44, 78ꢀ84.
17. Douglas, L.N.; McGuire, A.B.; Manzardo, A.M.; Butler, M.G. Highꢀ
resolution chromosome ideogram representation of recognized genes
for bipolar disorder. Gene 2016, 586, 136ꢀ147.
18. Shyn, S.I.; Shi, J.; Kraft, J.B.; Potash, J.B.; Knowles, J.A.; Weissman,
M.M.; Garriock, H.A.; Yokoyama, J.S.; McGrath, P.J.; Peters, E.J.;
Scheftner, W.A.; Coryell, W.; Lawson, W.B.; Jancic, D.; Gejman,
P.V.; Sanders, A.R.; Holmans, P.; Slager, S.L.; Levinson, D.F.; Hamꢀ
ilton, S.P. Novel loci for major depression identified by genomeꢀwide
association study of Sequenced Treatment Alternatives to Relieve Deꢀ
pression and metaꢀanalysis of three studies. Mol. Psychiatry 2011, 16,
202ꢀ215.
19. Li, W.; Ju, K.; Li, Z.; He, K.; Chen, J.; Wang, Q.; Yang, B.; An, L.;
Feng, G.; Sun, W.; Zhou, J.; Zhang, S.; Song, P.; Khan, R.; Ji, W.;
Shi, Y. Significant association of GRM7 and GRM8 genes with
schizophrenia and major depressive disorder in the Han Chinese
population. Eur. Neuropsychopharmacol. 2016, 26, 136ꢀ146.
20. Park, S.; Kim, B.N.; Cho, S.C.; Kim, J.W.; Kim, J.I.; Shin, M.S.; Yoo,
H.J.; Han, D.H.; Cheong, J.H. The metabotropic glutamate receptor
subtype 7 rs3792452 polymorphism is associated with the response to
methylphenidate in children with attentionꢀdeficit/hyperactivity disorꢀ
der. J. Child Adolesc. Psychopharmacol. 2014, 24, 223ꢀ227.
30. See Supporting Information for full experimental details.
32. Bubser, M.; Bridges, T.M.; Denker, D.; Gould, R.W.; Grannan, M.;
Noetzel, M.J.; Lamsal, A.; Niswender, C.M.; Daniels, J.S.; Poslusney,
M.S.; Melancon, B.J.; Tarr, J.C.; Byers, F.W.; Wess, J.; Duggan,
M.E.; Dunlop, J.; Wood, M.W.; Brandon, N.J.; Wood, M.R.;
Lindsley, C.W.; Conn, P.J.; Jones C.K. Selective activation of M4
muscarinic acetylcholine receptors reverses MKꢀ801ꢀinduced behavꢀ
ioral impairments and enhances associative learning in rodents. ACS
Chem. Neurosci. 2014, 5, 920ꢀ942.
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