762 Al-Majidi et al.
Asian J. Chem.
The third method to cyclization of Schiff bases (4-8) was
by using heating with sodium azide to give tetrazole deriva-
tives. FTIR spectrum of compounds 19-23 showed bands at
(1514-1512) cm-1 were due to the cyclic (N=N) stretching of
tetrazole ring. Also, the FTIR for these compounds appear
other absorptions bands at (1689-1683) cm-1, (1654-1600) cm-1
and (1556-1539) cm-1 due to ν(C=O) amide, ν(C=N) group
and ν(C=C) aromatic, respectively. FTIR characteristic data
are reported in Table-1.
ACKNOWLEDGEMENTS
Acknowledgement to Dr. Khalid and Dr. Faiq, the
Department of Chemistry, College of Science, Al-Qadisiyah
University for their help in the publication of this article.
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1H NMR spectrum data of compound 20 showed doublet
signal at δ = (1, 25) ppm due to (CH-CH3) protons, singlet
signal at δ = (3.03) ppm due to (N(CH3)2) protons, quartet
signal at δ = (3.38) due to (C-H) proton, multi signals at δ =
(7.25-8.23) ppm due to aromatic protons and singlet signal at
δ = (9.54) ppm due to (-(CO)-NH-) proton. 1H NMR spectral
data of compound 20 are listed in Table-2. 13C NMR spectral
data of compound 20 are listed in Table-3.
While 1H NMR spectrum data of compound 22 showed
doublet signal at δ = (1,25) ppm due to (CH-CH3) protons,
quartet signal at δ = (3.33) due to (C-H) proton, multi signals
at δ = (7.25-7.98) ppm due to phenyl and pyrrole ring protons,
singlet signal at δ = (8.24) ppm due to (N-H) proton of pyrrole
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1
proton. H NMR spectral data of compound 22 are listed in
Table-2. 13C NMR spectral data of compound 22 are listed in
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Antimicrobial activity: The results of antimicrobial activity
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compounds possess moderate activity against certain types of
bacteria, while it did not possess any activity against other
bacteria and Candida. Compound 12 possesses strong activity
against Staphylococcus aureus while compounds 3, 5 and 8
possess moderate activity against same bacteria. Compounds
2 and 12 possess moderate activity against Bacillus subtilis
while Pseudomonas aeruginosa was inhibited by compounds
2, 3 and 12 and showed moderate activity.As far as compound
12 possesses good activity against all types of bacteria
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Conclusion
A new class of 4(3H) quinazolinone derivatives, different
heterocyclic rings oxygen and nitrogen containing in structures
has been synthesized a simple and inexpensive method. The
prepared compounds identified by spectral methods [FTIR,
1H NMR and 13C NMR], furthermore we were studied the
effects of the preparing on four types strains of bacteria and
one yeast. Some of the prepared compounds possess moderate
to highly activity against for this types of bacteria and yeast in
study. The synthesis of further 4(3H) quinazolinone derivatives
of this novel class is under way.