Bioorganic and medicinal chemistry letters p. 1497 - 1500 (2002)
Update date:2022-08-05
Topics:
Yang, Ginger X
Chang, Linda L
Truong, Quang
Doherty, George A
Magriotis, Plato A
de Laszlo, Stephen E
Li, Bing
MacCoss, Malcolm
Kidambi, Usha
Egger, Linda A
McCauley, Ermengilda
Van Riper, Gail
Mumford, Richard A
Schmidt, John A
Hagmann, William K
Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify orally active VLA-4 antagonists was initiated. Herein, we report the discovery of a N-tetrahydrofuroyl-(L)-phenylalanine derivative (17) and related analogues as potent VLA-4 antagonists with good oral bioavailability.
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