Nucleosides and Nucleotides p. 995 - 1008 (1996)
Update date:2022-07-30
Topics: Synthesis Triazinic nucleosides β-ribosylamine nucleoside analogs Antiretroviral evaluation
Depelley, Jean
Granet, Robert
Kaouadji, Mourad
Krausz, Pierre
Piekarski, Salomon
Delebassee, Sylvie
Bosgiraud, Claudine
Various 5-alkyl-6-aza-5,6-dihydrouridines and 6-(β-D-ribopyranosyl)-5-alkyl-6-aza-5,6-dihydrouracils have been synthesized. A new regioselective method is described for coupling triazinic bases to the sugar unit. Different epimers were isolated. Antiretroviral activity against Visna virus was evaluated.
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